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| Product Name | Cholera Toxin, Vibrio cholerae, Inaba 569B |
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| Description | Two closely migrating major bands when examined by polyacrylamide gel electrophoresis in a nondenaturing system run at alkaline pH. Produced by Vibrio cholerae, cholera toxin (CT) is a multimeric enterotoxin that transfers ADP-ribose to a G protein, locking adenyl cyclase in an 'on' position. By binding to the membrane of enteric cells, cholera toxin stimulates the cellular adenylate cyclase system, causing the hyper-secretion of chloride and bicarbonate ions, which results in increased fluid secretion and the severe diarrhea characteristic of the disease cholera. The pentameric B subunit of CT binds with high efficiency to GM1 monosialoganglioside cell membrane receptors, present in many cell types, allowing its use experimentally in cell culture. Following binding, the toxin is endocytosed and travels retrogradely to the endoplasmic reticulum where the enzymatically active A subunit (CTA1) is translocated to the cytosol. Within the cytosol, CTA1 catalyzes the ADP-ribosylation of the |
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| Size | 1mg, 2mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 215931 |
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| Order / More Info | Cholera Toxin, Vibrio cholerae, Inaba 569B from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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