| 产品详情 |
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| Antigenic Specificity | Rb (Cleaved DRb-p70) |
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| Clone | 172C1094 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Frozen): 1:10-1:500, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rb (Cleaved DRb-p70) Monoclonal Antibody (172C1094). The retinoblastoma gene product (Rb) is a tumor suppressor protein and acts as cell cycle regulator (1). Recently, Rb has been shown to play a role in apoptosis. During apoptosis, Rb is subjected to cleavage by caspase-3 like protease. Caspase-3 cleaves Rb into 48 and 68kDa fragments (2-4). Cleavage of Rb would make it functionally inactive, causing release of E2F-1. The E2F-1 then may promote apoptosis (5). |
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| Immunogen | n/a |
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| Other Names | Cleaved Rb, Rb-p70, DRb-p70, delta RB-p70, pRb, pp110 |
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| Gene, Accession # | Entrez: 19645, 5925; Uniprot: P06400, P13405 |
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| Catalog # | MA1-41186 |
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| Price | |
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| Order / More Info | Rb (Cleaved DRb-p70) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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