| 产品详情 |
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| Antigenic Specificity | DIABLO |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 5 µg/mL, Immunoprecipitation: Assay Dependent, Western Blot: 1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DIABLO Polyclonal Antibody. The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases was recently identified and designated Smac/DIABLO. Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/capase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases. Smac/DIABLO is expressed in a variety of human and mouse tissues. |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | Entrez: 288753, 56616, 66593; Uniprot: Q9JIQ3, Q9NR28 |
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| Catalog # | PA5-19974 |
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| Price | |
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| Order / More Info | DIABLO Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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