| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | TMED10/TMP21 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human, mouse |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 20 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blot: 1:1,000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | TMED10/TMP21 Polyclonal Antibody. TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also |
|---|
| Immunogen | n/a |
|---|
| Other Names | Transmembrane emp24 domain-containing protein 10 , Transmembrane protein Tmp21 , 21 kDa transmembrane trafficking prote |
|---|
| Gene, Accession # | Entrez: 10972, 68581; Uniprot: P49755, Q9D1D4 |
|---|
| Catalog # | A305-227A-T |
|---|
| Price | |
|---|
| Order / More Info | TMED10/TMP21 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|