| 产品详情 |
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| Antigenic Specificity | GALE |
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| Clone | OTI1C4 |
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| Host Species | Mouse |
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| Reactive Species | canine, human, nonhuman primate, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:500-1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | GALE Monoclonal Antibody (OTI1C4). This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, |
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| Immunogen | n/a |
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| Other Names | UDP-glucose 4-epimerase; Galactowaldenase; UDP-N-acetylgalactosamine 4-epimerase; UDP-GalNAc 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-galactose 4-epimerase; GALE |
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| Gene, Accession # | Entrez: 100855555, 114860, 2582, 710553; Uniprot: P18645, Q14376 |
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| Catalog # | MA5-25349 |
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| Price | |
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| Order / More Info | GALE Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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