| 产品详情 |
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| Antigenic Specificity | Cortactin |
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| Clone | 4C6 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1/200 - 1/1000, Western Blot: 1/500 - 1/2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Cortactin Monoclonal Antibody (4C6). Cortactin (Cttn) is a ubiquitous actin-binding protein that was originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape. Cortactin also plays a role in the formation of lamellipodia and cell migration. It is accumulated in peripheral, actin-enriched structures of cells suggesting that cortactin facilitates actin network formation. Cortactin has four major domains of interest the N-terminal acidic (NTA) and tandem repeats domains and the C-terminal proline-rich and SH3 Domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin is involved in promoting cell motility and invasion, including a critical role in inva |
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| Immunogen | n/a |
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| Other Names | EMS1, 1110020L01Rik; amplaxin; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); oncogene EMS1; src substrate cortactin |
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| Gene, Accession # | Entrez: 13043, 2017; Uniprot: Q14247, Q60598 |
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| Catalog # | MA5-15831 |
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| Price | |
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| Order / More Info | Cortactin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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