| 产品详情 |
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| Antigenic Specificity | Securin |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Immunohistochemistry: 1:50-1:100, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Securin Polyclonal Antibody. PTTG1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The protein has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. This protein contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the protein can act as a transactivation domain. It is mainly a cy |
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| Immunogen | n/a |
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| Other Names | Securin; Pituitary tumor-transforming gene 1 protein; hPTTG; Tumor-transforming protein 1; Esp1-associated protein; PTTG1; TUTR1; PTTG; EAP1; PTTG1 |
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| Gene, Accession # | Entrez: 9232; Uniprot: O95997 |
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| Catalog # | PA5-14240 |
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| Price | |
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| Order / More Info | Securin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 26622390 |
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| 产品资料 |
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