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| Product Name | Recombinant Human E3 ubiquitin-protein ligase MIB1 (MIB1), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 40.1kDa. Partial: 5-332aa. N-terminal 6xHis-tagged. Homo sapiens (Human). E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.1 Publication |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | DAPK-interacting protein 1; DIP-1Mind bomb homolog 1Zinc finger ZZ type with ankyrin repeat domain protein 2 |
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| Gene, Accession, CAS # | MIB1, UniProt: Q86YT6 |
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| Catalog # | RPC24301 |
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| Price | |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase MIB1 (MIB1), partial from BIOMATIK |
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| Product Specific References | n/a |
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