| 产品详情 |
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| Product Name | Recombinant Human E3 ubiquitin-protein ligase MYLIP (MYLIP) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 76.9kDa. Full Length: 1-445aa. N-terminal GST-tagged. Homo sapiens (Human). E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Inducible degrader of the LDL-receptor; IdolMyosin regulatory light chain interacting protein; MIR |
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| Gene, Accession, CAS # | MYLIP, UniProt: Q8WY64 |
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| Catalog # | RPC23483 |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase MYLIP (MYLIP) from BIOMATIK |
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| Product Specific References | n/a |
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