| 产品详情 |
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| Product Name | Recombinant Human E3 ubiquitin-protein ligase NRDP1 (RNF41) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 62.9kDa. Full Length: 1-317aa. N-terminal GST-tagged. Homo sapiens (Human). Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | RING finger protein 41 |
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| Gene, Accession, CAS # | RNF41, UniProt: Q9H4P4 |
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| Catalog # | RPC23673 |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase NRDP1 (RNF41) from BIOMATIK |
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| Product Specific References | n/a |
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