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| Product Name | Recombinant Human E3 ubiquitin-protein ligase SMURF2 (SMURF2) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 88.2kDa. Full Length: 1-748aa. N-terminal 6xHis-tagged. Homo sapiens (Human). E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | SMAD ubiquitination regulatory factor 2SMAD-specific E3 ubiquitin-protein ligase 2 |
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| Gene, Accession, CAS # | SMURF2, UniProt: Q9HAU4 |
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| Catalog # | RPC25528 |
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| Order / More Info | Recombinant Human E3 ubiquitin-protein ligase SMURF2 (SMURF2) from BIOMATIK |
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| Product Specific References | n/a |
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