| 产品详情 |
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| Antigenic Specificity | Phospho-IRF3 (Ser385) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-IRF3 (Ser385) Polyclonal Antibody. IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-terminal Ser and Thr residues (between 385 and 405), leading to its association with the p300/CBP coactivator protein that promotes DNA binding and transcriptional activity. During infection, IRF-3 is likely activated through a pathway that includes activation of Toll-like receptors and a kinase complex that incl |
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| Immunogen | n/a |
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| Other Names | IRF3, IRF-3, IRF3, Interferon regulatory factor 3 |
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| Gene, Accession # | Entrez: 292892, 3661, 54131; Uniprot: P70671, Q14653 |
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| Catalog # | PA5-36775 |
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| Price | |
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| Order / More Info | Phospho-IRF3 (Ser385) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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