| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | SMURF2 |
|---|
| Clone | 4HCLC |
|---|
| Host Species | Recombinant Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG |
|---|
| Format | purified |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Western Blot: 1-2 µg/mL |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | SMURF2 Antibody (4HCLC), ABfinity™ Rabbit Oligoclonal. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2 |
|---|
| Immunogen | n/a |
|---|
| Other Names | SMAD Specific E3 Ubiquitin Protein Ligase 2; E3 ubiquitin-protein ligase SMURF2; hSMURF2 |
|---|
| Gene, Accession # | Entrez: 64750; Uniprot: Q9HAU4 |
|---|
| Catalog # | 711323 |
|---|
| Price | |
|---|
| Order / More Info | SMURF2 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|