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| Antigenic Specificity | SMURF2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Immunofluorescence: 1:10-1:50, Immunohistochemistry: 1:50-1:100, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SMURF2 Polyclonal Antibody. SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. |
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| Immunogen | n/a |
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| Other Names | E3 ubiquitin-protein ligase SMURF2; Smad ubiquitination regulatory factor 2; Smad-specific E3 ubiquitin ligase 2; |
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| Gene, Accession # | Entrez: 64750; Uniprot: Q9HAU4 |
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| Catalog # | PA5-11946 |
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| Price | |
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| Order / More Info | SMURF2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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