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| Antigenic Specificity | MLF1 |
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| Clone | OTI2D6 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1:100, Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:500-1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MLF1 Monoclonal Antibody (OTI2D6). MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. |
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| Immunogen | n/a |
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| Other Names | Myeloid leukemia factor 1; Myelodysplasia-myeloid leukemia factor 1; MLF-1 |
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| Gene, Accession # | Entrez: 4291; Uniprot: P58340 |
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| Catalog # | MA5-25976 |
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| Price | |
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| Order / More Info | MLF1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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