| 产品详情 |
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| Antigenic Specificity | NUMB |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | bovine, human, mouse, nonhuman primate, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 5-10 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | NUMB Polyclonal Antibody. Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator. |
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| Immunogen | n/a |
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| Other Names | C14orf41, S171, c14_5527, h-Numb, protein numb homolog |
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| Gene, Accession # | Entrez: 18222, 29419, 512187, 8650; Uniprot: P49757, Q2LC84, Q9QZS3 |
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| Catalog # | PA5-23486 |
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| Price | |
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| Order / More Info | NUMB Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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