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| Product Name | 5α-hydroxy-6-keto Cholesterol |
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| Description | Cholesterol is the most abundant neutral lipid present in the surfactant of the lung epithelial lining fluid. The double bond between carbons 5 and 6 of cholesterol is susceptible to attack by ozone within this surfactant environment. 6-Oxo-3,5,-diol is a major metabolite of cholesterol formed during exposure of lung epithelial cells to ozone, with formation of 5β,6β-epoxycholesterol as a predominant precursor.{13448} Exposure of C57BL/6J mice to 0.5-3 ppm ozone produced a dose-dependent formation of 6-oxo-3,5,-diol which was detectable in the bronchalveolar lavage fluid, lavaged cells, and lung homogenates.{13449} 6-Oxo-3,5-diol is a potent inhibitor of cholesterol synthesis in human bronchial epithelial cells with an IC50 of 350 nM and exhibits significant cytotoxicity in the low µM range.{13448} Therefore, the toxic effects of ozone may be mediated by formation oxysterols of this type. |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-Oxo-3,5-diol|Cholestane-6-oxo-3β,5α-diol |
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| Gene, Accession, CAS # | CAS: 13027-33-3 |
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| Catalog # | 10007601-10 |
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| Order / More Info | 5α-hydroxy-6-keto Cholesterol from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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