| 产品详情 |
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| Antigenic Specificity | WT1 |
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| Clone | 6F-H2 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Frozen): 1: 400, Immunohistochemistry (Paraffin): 1:400, Immunoprecipitation: 2-10 µg/mL lysate, Western Blot: 2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | WT1 Monoclonal Antibody (6F-H2). Wilms' tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and, like retinoblastoma, is observed in both sporadic and inherited forms. The Wilms' tumor locus has been mapped at chromosome 11p13 as a tumor suppressor gene which encodes a DNA binding protein with four zinc fingers and a glutamine-proline rich amino terminus. The Wilms' tumor protein binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators. However, in contrast to Egr transcription factors, WT1 behaves as a transcriptional repressor in transient transfection assays with synthetic promotor constructs. |
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| Immunogen | n/a |
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| Other Names | Wilms tumor protein, WT33, WT1 |
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| Gene, Accession # | Entrez: 22431, 7490; Uniprot: P19544, P22561 |
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| Catalog # | MA1-46028 |
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| Price | |
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| Order / More Info | WT1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 16185300, 22558480, 24987706, 27023710, 27062662 |
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