| 产品详情 |
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| Product Name | AS-252424 |
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| Description | AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ IC50= 30 nM, PI3Ka IC50=940 nM, PI3Kb IC50=20,000 nM and PI3Kd IC50= 20,000 nM respectively. AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50=230 nM. In a mouse model of peritonitis, PI 3-K? this compound inhibited neutrophil recruitment 35% at a dose of 10 mg/kg. MW: 305.3. Purity ≥98% |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AS-252424; AS 252424; AS252424; 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione; (E)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione; PI3Kg/CKII Inhibitor |
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| Gene, Accession, CAS # | CAS: 900515-16-4 |
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| Catalog # | B1611-5 |
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| Price | |
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| Order / More Info | AS-252424 from BIOVISION, INC. |
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| Product Specific References | n/a |
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