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| Product Name | CLU, Recombinant, Human, aa23-224, His-Tag (Clusterin) |
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| Description | Purity ~90% (SDS-PAGE). Isoform 1 functions as Extracellular domain chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complent. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcripti |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Aging-associated gene 4 protein, Apolipoprotein J, Apo-J Complement cytolysis inhibitor, CLI Complement-associated protein SP-40,40Ku70-binding protein 1 NA1/NA2 Testosterone-repressed prostate message 2, TRPM-2 |
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| Gene, Accession, CAS # | SwissProt: P10909 |
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| Catalog # | 372795 |
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| Order / More Info | CLU, Recombinant, Human, aa23-224, His-Tag (Clusterin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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