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| Product Name | Recombinant Escherichia coli Transcriptional regulatory protein phoP (phoP) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 30.5kDa. Full Length: 1-223aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Escherichia coli (strain K12). Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg2+ environments and the control of acid resistance genes. In low periplasmic Mg2+, PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg2+, PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes. Feedback inhibited by MgrB, which seems to bind PhoQ, altering its activity and that of downstream effector PhoP. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, or treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | n/a |
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| Gene, Accession, CAS # | phoP, UniProt: P23836 |
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| Catalog # | RPC22495 |
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| Order / More Info | Recombinant Escherichia coli Transcriptional regulatory protein phoP (phoP) from BIOMATIK |
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| Product Specific References | n/a |
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