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| Product Name | Recombinant Vaccinia virus Protein E3 (E3L) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 28.5kDa. Full Length: 1-190aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Vaccinia virus (strain Copenhagen) (VACV). The C-terminus binds to and sequesters double-stranded RNA (dsRNA) synthesized during viral infection. This binding acts to 'mask' the dsRNA thereby preventing recognition and subsequent activation of EIF2AK2/PKR. The N-terminus is required for phosphorylation regulation of the translation initiation factor EIF2S1, but without affecting cytosolic protein translation. Blocks the phosphorylation and subsequent activation of IRF3 and IRF7 kinases, that are required for interferon-alpha (IFN-alpha) gene expression. Also inhibits NF-kappa-B activation and the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | p25 |
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| Gene, Accession, CAS # | E3L, UniProt: P21081 |
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| Catalog # | RPC25635 |
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| Order / More Info | Recombinant Vaccinia virus Protein E3 (E3L) from BIOMATIK |
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| Product Specific References | n/a |
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