| 产品详情 |
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| Antigenic Specificity | ATM |
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| Clone | C.74.4 |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ATM Monoclonal Antibody (C.74.4). Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer. The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1. The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens. The ATM's C-terminal region has extensive homology to the cataly |
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| Immunogen | n/a |
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| Other Names | A-T mutated; AT mutated; TEL1, telomere maintenance 1, homolog; serine-protein kinase ATM |
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| Gene, Accession # | Entrez: 11920, 472; Uniprot: Q13315, Q62388 |
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| Catalog # | MA5-14871 |
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| Price | |
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| Order / More Info | ATM Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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