| 产品详情 |
| Edit |   |
|---|
| Product Name | Chk2, Human, Recombinant, NT, GST-His-Tag (Checkpoint Kinase 2, Rad 53) |
|---|
| Description | Purity ≥ 80% by SDS-PAGE. Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both functionas essential components in the G2 DNA damage checkpoint by phophorylating Cdc25C in response to DNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown that Chk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylated form of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation by Chk1. Human Check point kinase 2 (CHK2) (GenBank Accession No. NM_007194), full length, with N-terminal GST-HIS6-tag, expressed in an Baculovirus infected Sf9 cell expression system. The theoretical MW is |
|---|
| Size | 10ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | Accession: NM_007194 |
|---|
| Catalog # | C4201-02 |
|---|
| Price | |
|---|
| Order / More Info | Chk2, Human, Recombinant, NT, GST-His-Tag (Checkpoint Kinase 2, Rad 53) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|