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| Product Name | Recombinant Human Complement C4-B (C4B), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 35.1kDa. Partial: 1454-1744aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complent pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.Derived from proteolytic degradation of complent C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Basic complement C4C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 |
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| Gene, Accession, CAS # | C4B, UniProt: P0C0L5 |
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| Catalog # | RPC25071 |
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| Order / More Info | Recombinant Human Complement C4-B (C4B), partial from BIOMATIK |
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| Product Specific References | n/a |
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