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| Product Name | HGK, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). HGK is the mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) and a member of the serine/threonine protein kinase family. HGK has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by HGK can be inhibited by dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggest that this kinase functions through the MAP3K7-MAP2K4-MAP2K7 kinase cascade and mediates TNF-a signaling. HGK-dependent signaling inhibits PPAR-responsive gene expression, adipogenesis, and insulin-stimulated glucose transport. Source: Recombinant protein corresponding to human HGK, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~64kD Specific Activity: 54nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HGK, Recombinant, Human, GST-Tag (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4, MAP4K4, NIK, KIAA0687) |
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| Gene, Accession, CAS # | Accession: NP_004825, SwissProt: O95819 |
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| Catalog # | 500066 |
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| Order / More Info | HGK, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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