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| Product Name | Geldanamycin (Streptomyces hygroscopicus) 98+% |
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| Description | Purity ≥98%. Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. A potent antitumor 1 and potent inhibitor of p60c-crc tyrosine kinase, erb B2,2 EGF receptor tyrosine kinase and non-receptor tyrosine kinases. 3, Geldanamycin binds specifically and inhibits the chaperone protein Hsp90.2 Geldanamycin acts by binding to the 90kD heat-shock protein (Hsp90) essential to maintain the conformation, stability, activity and cellular localization of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1alpha, survivin and telomerase hTERT. Related to: Antibiotic TAN 420C, Antibiotic TAN 420E, Herbimycin A, Herbimycin B. |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione 9-Carbamate; (+)-Geldanamycin; NSC 122750; NSC 212518; BRN1633093 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | G2024-50 |
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| Order / More Info | Geldanamycin (Streptomyces hygroscopicus) 98+% from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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