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| Antigenic Specificity | CISD2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µl |
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| Concentration | n/a |
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| Applications | Western Blot: 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CISD2 Polyclonal Antibody. Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype. |
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| Immunogen | n/a |
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| Other Names | CDGSH iron-sulfur domain-containing protein 2, cisd2 |
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| Gene, Accession # | Entrez: 67006; Uniprot: Q9CQB5 |
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| Catalog # | PA5-49425 |
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| Price | |
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| Order / More Info | CISD2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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