| 产品详情 |
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| Product Name | LY2811376 |
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| Description | A non-peptide inhibitor of BACE1 (IC50 = 239 nM) that demonstrates ~10-fold selectivity over BACE2 and >50-fold selectivity over other aspartyl proteases; decreases Aβ in APP-overexpressing cells and transgenic animal models and reduces C99 and sAPPβ, the two primary APP cleavage products generated by BACE1 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Alzheimer's disease BACE1 inhibitor amyloid-β neurodegeneration protease β-secretase research biochemical inhibit neuroscience BACE-1 accumulation Aβ peptide brain primary cause progression sequential proteolytic cleavage precursor protein APP γ-secretase LY-2811376 non-peptide nonpeptide synthetic APP-overexpressing cells transgenic animal model dose-dependent decrease reduce C99 sAPPβ product |
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| Gene, Accession, CAS # | CAS: 1194044-20-6 |
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| Catalog # | 16712-10 |
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| Price | |
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| Order / More Info | LY2811376 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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