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EGFR, Recombinant, Human, GST-Tag (Epidermal Growth Factor Receptor, ERBB, mENA, ERBB1, HER1) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | EGFR, Recombinant, Human, GST-Tag (Epidermal Growth Factor Receptor, ERBB, mENA, ERBB1, HER1) |
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| Description | Purified (~70-90%). EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. Source: Recombinant protein corresponding to human EGFR, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~89kD Specific Activity: 60nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_005228 |
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| Catalog # | 499942 |
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| Order / More Info | EGFR, Recombinant, Human, GST-Tag (Epidermal Growth Factor Receptor, ERBB, mENA, ERBB1, HER1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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