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| Product Name | GW 1100, GPR40 Antagonist |
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| Description | Purity ~97% (HPLC). A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Selectively blocks GPR40-mediated intracellular Ca2+ release stimulated by GPR40 Agonist GW9508 and linoleic acid (pIC50 of 5.99 in GPR40 expressing HEK293 cells) with no effect on GPR120-mediated activation. Shown to significantly reverse glucose-induced insulin secretion potentiated by GW9508 and only partially reduce linoleic acid effect in MIN6 cells. Formula: C27H25FN4O4S Solubility: DMSO Molecular Weight: 520.6 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GW 1100, GPR40 Antagonist (SB376752, 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217408 |
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| Price | |
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| Order / More Info | GW 1100, GPR40 Antagonist from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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