| 产品详情 |
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| Antigenic Specificity | CD180 |
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| Clone | G28-8 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 2 µg/mL, Functional Assay: Assay Dependent, Immunoprecipitation: Assay dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD180 Monoclonal Antibody (G28-8). CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1 , and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size. |
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| Immunogen | n/a |
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| Other Names | LY64, Ly78, CD180 antigen, lymphocyte antigen 64, lymphocyte antigen-64 radioprotective, radioprotective 105 kDa protein |
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| Gene, Accession # | Entrez: 4064; Uniprot: Q99467 |
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| Catalog # | MA1-10125 |
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| Price | |
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| Order / More Info | CD180 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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