| 产品详情 |
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| Product Name | SKA-121 |
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| Description | A positive-gating modulator of IKCa1/KCa3.1 channels (EC50 = 109 nM); selective for KCa3.1 over KCa2.1, KCa2.2 and KCa2.3 (EC50s = 8,700, 6,800, and 4,400 nM, respectively), KCa1.1 as well as voltage-gated potassium and sodium channels; potentiates calcium-evoked KCa currents by approximately 7-fold (1 µM) as well as calcium-evoked and basal KCa currents; potentiates bradykinin-induced endothelium-dependent relaxation (EC50 = 7.9 nM) in large porcine coronary arteries ex vivo; lowers MAP ) by approximately 20 and 25 mm Hg in normo- and hypertensive mice (100 mg/kg) |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SKA121 TRAM34 |
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| Gene, Accession, CAS # | CAS: 1820708-73-3 |
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| Catalog # | 9003088-10 |
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| Price | |
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| Order / More Info | SKA-121 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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