| 产品详情 |
| Edit |   |
|---|
| Product Name | DDX58, Recombinant, Human, aa1-430, His-Tag (Probable ATP-dependent RNA Helicase DDX58) |
|---|
| Description | Purity ~90% (SDS-PAGE). Innate immune receptor which acts as a Cytoplasmic domain sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons ( |
|---|
| Size | 10ug, 50ug, 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | DEAD box protein 58RIG-I-like receptor 1, RLR-1 Retinoic acid-inducible gene 1 protein, RIG-1 Retinoic acid-inducible gene I protein, RIG-I |
|---|
| Gene, Accession, CAS # | SwissProt: O95786 |
|---|
| Catalog # | 373015 |
|---|
| Price | |
|---|
| Order / More Info | DDX58, Recombinant, Human, aa1-430, His-Tag (Probable ATP-dependent RNA Helicase DDX58) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|