| 产品详情 |
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| Antigenic Specificity | Lck |
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| Clone | A17013D |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), ICC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Lck. Lck is a 56 kD tyrosine protein kinase and a member of the src subfamily that contains both an SH2 and SH3 domain. Alternatively spliced isoforms of Lck have been reported. Lck is a cytoplasmic protein bound to CD4 and CD8 in T lymphocytes that participates in antigen-induced T cell activation through phosphorylation of the T cell receptor zeta chain. Lck is activated upon T cell receptor engagement and is involved in the onset of cell cycle progression induced by interleukin-2. Phosphorylation by Csk downregulates the activity of Lck. In addition to CD4 and CD8, Lck has been reported to interact with PI3K through its SH3 domain and tyrosine phosphorylated KHDRBS1/p70 through its SH2 domain. In addition, Lck has been shown to associate with the SAP transmembrane tyrosine phosphatase. |
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| Immunogen | Human Lck peptide phosphorylated around Tyr505. |
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| Other Names | Proto-oncogene tyrosine kinase lck, p56-Lck, T-cell specific protein tyrosine kinase |
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| Gene, Accession # | Gene ID: 3932 |
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| Catalog # | 601001 |
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| Price | |
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| Order / More Info | Lck Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 产品资料 |
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