| 产品详情 |
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| Antigenic Specificity | RNF43 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 100ug |
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| Concentration | 0.5-1mg/ml, actual concentration varies by lot. |
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| Applications | ELISA, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit IgG polyclonal Picoband™ antibody for RNF43 detection. Tested with WB, Direct ELISA in Human;Mouse;Rat. No cross reactivity with other proteins. RNF43 is a HAP95 (AKAP8L) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer. The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. |
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| Immunogen | E. coli-derived human RNF43 recombinant protein (Position: G24-Y197). |
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| Other Names | E3 ubiquitin-protein ligase RNF43; RING finger protein 43; RING-type E3 ubiquitin transferase RNF43; RNF43 |
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| Gene, Accession # | RNF43, UniProt: Q68DV7 |
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| Catalog # | A01694-1 |
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| Price | |
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| Order / More Info | RNF43 Antibody from BOSTER BIO |
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| Product Specific References | n/a |
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| 产品资料 |
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