| 产品详情 |
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| Product Name | ST3Gal1, soluble fragment, Human Recombinant |
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| Description | ST3Gal1 catalyzes transfer of the sialic acid Neu5Ac from CMP-Neu5Ac (cytidine 5'-monophosphono-N-acetylneuraminic acid) to Galβ1, 3GalNAc on glycoproteins or glycolipids in an α2, 3 linkage. It is a type II transmembrane protein that is normally localized to the golgi, but can be cleaved to yield a soluble product. Sialylation of the core-1 structure (Galβ1, 3GalNAc-O-Ser/Thr) by ST3Gal1 prevents formation of the core-2 structure (GlcNAcβ1, 6(Galβ1, 3)GalNAc-Ser/Thr). On CD8+ T-cells this prevents induction of either apoptosis or differentiation into memory cells. Overexpression of ST3Gal1 in breast cancer cells correlated with the presence of the core-1 based marker SM3, whereas healthy cells displayed a higher r |
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| Size | 5 µg |
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| Concentration | 100 ug/ml |
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| Applications | RUO |
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| Other Names | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1, Gal-NAc6S, Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase, SIATFL, ST3Gal I |
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| Gene, Accession, CAS # | ST3GAL1, Gene ID: 6482, Accession: Q11201 |
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| Catalog # | P1224-5 |
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| Price | |
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| Order / More Info | ST3Gal1, soluble fragment, Human Recombinant from BIOVISION, INC. |
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| Product Specific References | n/a |
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