| 产品详情 |
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| Antigenic Specificity | MSH2 |
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| Clone | 2MSH01 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 500 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MSH2 Monoclonal Antibody (2MSH01). MSH2 is involved in DNA repair as a mismatch repair protein, and mutations of MSH2 are found in approximately 50% of inherited non polyposis colorectal carcinoma. Defects in MSH2 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. it is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world. |
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| Immunogen | n/a |
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| Other Names | COCA1, FCC1, HNPCC, HNPCC1 |
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| Gene, Accession # | Entrez: 4436; Uniprot: P43246 |
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| Catalog # | MA1-12621 |
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| Price | |
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| Order / More Info | MSH2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15382045, 16534870, 16924473, 17724798 |
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