| 产品详情 |
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| Product Name | JNJ 27141491 |
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| Description | Potent, noncompetitive human CCR2 antagonist; inhibits MCP-1-induced Ca2+ mobilization in hCCR2-CHO cells (IC50 = 13 nM). Exhibits selectivity for CCR2 over CCR1, CCR3-8 and CXCR1-3. Delays onset and reduces neurological signs in an experimental autoimmune encephalomyelitis model of multiple sclerosis in hCCR2 knock-in mice. Orally active. Purity 98%. MW (observed): 379.38 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[(1S)-1-(3,4-Difluorophenyl)propyl]-2,3-dihydro-5-(5-isoxazolyl)-2-thioxo-1H-imidazole-4-carboxylic acid methyl ester |
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| Gene, Accession, CAS # | CAS: 871313-59-6 |
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| Catalog # | 5176/10 |
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| Order / More Info | JNJ 27141491 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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