| 产品详情 |
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| Product Name | GPCR-Helix 8 Signaling Inhibitor, JF5 |
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| Description | Purity ~92% (HPLC). A cell-permeable quinolinimine compound that acts as a selective, potent blocker of G-protein coupled receptors (GPCR) that contain a constrained eighth helix (H8). The inhibition is selective and blocks G-protein signaling mediated via Gaq, but not Ga12. A non-orthosteric antagonist of PAR1 (IC50=4uM) that is shown to inhibit PAR1 and CCR-4 induced platelet aggregation without affecting PAR4 mediated aggregation. Shown to inhibit thrombus formation following vascular injury (IC50 ~1mg/kg). Also acts as a potent, non-competitive blocker of a2A-adrenergic receptors (IC50=2.5uM as shown by a decrease in 3H-yohimbine binding). Formula: C17H22N2 · HI Solubility: DMSO Molecular Weight: 382.3 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GPCR-Helix 8 Signaling Inhibitor, JF5 (GPCR-H8 Signaling Inhibitor, JF5, 4-Pentyl-2,3-dihydro-1H-cyclopenta[b]quinolin-9-imine, HI, 4-Pentyl-1,2,3,4-tetrahydro-9H-cyclopenta[b]quinolin-9-imine, HI) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217390 |
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| Order / More Info | GPCR-Helix 8 Signaling Inhibitor, JF5 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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