| 产品详情 |
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| Antigenic Specificity | LAT |
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| Clone | LAT.10-17 (10-17) |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 5 µg/mL, Western Blot: 5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LAT Monoclonal Antibody (LAT.10-17 (10-17)), eBioscience™. LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation. |
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| Immunogen | n/a |
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| Other Names | Linker for activation of T cells, pp36 |
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| Gene, Accession # | Entrez: 27040; Uniprot: O43561 |
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| Catalog # | 14-9967-82 |
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| Price | |
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| Order / More Info | LAT Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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