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| Antigenic Specificity | BRCA1 Associated Protein (BRAP) |
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| Clone | 1E7-C9-D10-B10 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | affinity purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. Subunit structure: Interacts with the nuclear localization signal of BRCA1 and with the N-terminal of KSR1. The C-terminal portion of BCRA1 interacts with DDB1. Subcellular location: CytoplasmSequence similarities: Contains 1 RING-type zinc finger. Contains 1 UBP-type zinc finger. |
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| Immunogen | Purified recombinant human BRAP protein fragments expressed in E.coli. |
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| Other Names | imp|MGC68778|zgc:92894|BRAP|BRAP2|IMP|RNF52|3010002G07Rik |
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| Gene, Accession # | Gene ID: 8315 |
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| Catalog # | ABIN2169483 |
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| Price | |
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| Order / More Info | BRCA1 Associated Protein (BRAP) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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