| 产品详情 |
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| Antigenic Specificity | ADAP |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 10 µg/mL, Immunofluorescence: 20 µg/mL, Western Blot: 0.5-1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ADAP Polyclonal Antibody. The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoform |
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| Immunogen | n/a |
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| Other Names | ADAP, PRO0823, SLAP-130; FYB-120/130; FYN-T-binding protein; FYN-binding protein; SLP-76-associated phosphoprotein; adhesion and degranulation-promoting adaptor protein; p120/p130 |
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| Gene, Accession # | Entrez: 2533; Uniprot: O15117 |
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| Catalog # | PA5-20401 |
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| Price | |
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| Order / More Info | ADAP Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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