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| Product Name | Acidic Mammalian Chitinase Inhibitor, Bisdionin F |
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| Description | Purity ~95% (HPLC). A cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC50=0.92uM and Ki=0.42uM for hAMCase, and IC50=2.2uM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice. Formula: C16H18N8O4 Molecular Weight: 386.4 Solubility: DMSO (5mg/ml, clear, nearly colorless solution) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AMCase Inhibitor, 3,7-dimethyl-1-(3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)propyl)-1H-purine-2,6(3H,7H)-dione |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217138 |
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| Order / More Info | Acidic Mammalian Chitinase Inhibitor, Bisdionin F from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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