| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Mouse IL-6 (ELISA Std.) |
|---|
| Description | IL-6 is a multifunctional cytokine that can regulate various immune and inflammatory responses. Several studies have suggested a crucial role for IL-6 in angiogenesis. The use of mice deficient in IL-6 (–/–) demonstrated a critical role for this protein in a mouse model of lung angiogenesis. IL-6 has been shown to cause proliferation and migration of systemic endothelial cells in culture. The classical responsiveness to IL-6 is governed by a receptor complex consisting of two membrane-bound subunits, an 80-kD cognate -chain (IL-6R ), and a ubiquitously expressed 130-kD β-chain receptor (gp130) which acts as the universal signal-transducing element for all IL-6 family cytokines. Alternatively, IL-6 regulation of leukocyte trafficking relies upon signaling via its soluble IL-6R (termed IL-6 trans-signaling). IL-6 plays a major role in regulating neutrophil clearance during acute peritoneal inflammation; as a result of specific down-regulation of neutrophil-attracting chemokine (CXCL1/KC) production. IL-6 is a key factor that reciprocally regulates Th17 and Foxp3(+) Treg differentiation by inhibition of TGF-beta induced Foxp3 and induction of RORgammat, a Th17 lineage-specific transcription factor. |
|---|
| Size | 4 pack |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA |
|---|
| Other Names | Interleukin-6, Interferon-b2, BSF-2, CDF, HSF, HPGF |
|---|
| Gene, Accession, CAS # | Gene ID: 16193 |
|---|
| Catalog # | 575709 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Mouse IL-6 (ELISA Std.) from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|