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| Product Name | Recombinant Human Zinc finger protein GLI2 (GLI2), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 30.5kDa. Partial: 412-641aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856).By similarity1 Publication5 Publications Isoform 1, isoform 2, isoform 3 and isoform 4: Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). Are involved in the smoothened (SHH) signaling pathway (PubMed:18455992).3 Publications Isoform 5: Acts as a transcriptional repressor. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | GLI family zinc finger protein 2; Tax helper protein |
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| Gene, Accession, CAS # | GLI2, UniProt: P10070 |
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| Catalog # | RPC23822 |
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| Order / More Info | Recombinant Human Zinc finger protein GLI2 (GLI2), partial from BIOMATIK |
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| Product Specific References | n/a |
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