| 产品详情 |
| Edit |   |
|---|
| Product Name | Interleukin 31 (IL31) (AA 24-164) (Active) protein |
|---|
| Description | Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM Rbeta). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFNgamma on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.Alternative Names: Interleukin-31, IL-31, IL31 |
|---|
| Size | 500 µg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | IL31|IL-31|1700013B14Rik |
|---|
| Gene, Accession, CAS # | Gene ID: 386653 |
|---|
| Catalog # | ABIN1690821 |
|---|
| Price | |
|---|
| Order / More Info | Interleukin 31 (IL31) (AA 24-164) (Active) protein from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|