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| Product Name | Interleukin 33 (IL33) (AA 112-270) (Active) protein |
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| Description | Interleukin-33 (IL-33) is a proinflammatory cytokine that belongs to the IL-1 family. IL-33 is expressed in a variety of cells, including epithelial and endothelial cells, smooth muscle cells, macrophages and fibroblasts. The primary receptors for IL-33 are ST2 and IL-1 receptor accessory protein (IL-1RAcP), both of which belong to the IL-1 receptor family. IL-33 is localized to the nucleus of resting cells where it binds to chromatin in the H2A-H2B histone complex as a transcriptional suppressor. IL-33 is secreted by cells during injury which induces a T-helper 2 type inflammatory response. Evidence suggests IL-33 plays a role in autoimmune disease. IL-33's interaction with ST2 can drive allergic pathology and IL-33 has been reported to play a role in the development of rheumatoid arthritis and systemic lupus erythematosus.Recombinant humanInterleukin-33 (rhIL-33) produced in E. coli is a single non-glycosylated polypeptide chain containing 159 amino acids. A fully biologically active molecule, rhIL-33 has a molecular mass of 18.0 kDa analyzed by reducing SDS-PAGE. Synonyms: IL-1F11, NF-HEV |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL33|C9orf26|DVS27|IL1F11|NF-HEV|NFEHEV|RP11-575C20.2|9230117N10Rik|Il-33|Il1f11|RGD1311155 |
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| Gene, Accession, CAS # | Gene ID: 90865 |
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| Catalog # | ABIN2018109 |
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| Order / More Info | Interleukin 33 (IL33) (AA 112-270) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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