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| Product Name | KDR, Recombinant, Human, GST-Tag (Kinase Insert Domain Receptor, FLK1, VEGFR, VEGFR2) |
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| Description | Purified (~70-90%). KDR (or kinase insert domain receptor) is a growth factor receptor tyrosine kinase that was originally isolated from human endothelial cells where it plays a pivotal role in endothelial cell proliferation and differentiation. KDR and its mouse homolog Flk1 bind VEGF with high affinity and are implicated in the development of new blood vessels (angiogenesis). The expression levels of VEGF and KDR are highly correlated during the normal development of the ocular vasculature in humans. Induction of angiogenesis is a critical step in tumor progression, and inhibitors of KDR have been demonstrated both to induce tumor regression and reduce metastatic potential in preclinical models. Source: Recombinant protein corresponding to human KDR, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~110kD Specific Activity: 70nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_002253, SwissProt: P35968 |
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| Catalog # | 500195 |
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| Order / More Info | KDR, Recombinant, Human, GST-Tag (Kinase Insert Domain Receptor, FLK1, VEGFR, VEGFR2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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