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| Product Name | Recombinant Zaire ebolavirus Polymerase cofactor VP35 (VP35) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 41.4kDa. Full Length: 1-340aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus). Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | n/a |
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| Gene, Accession, CAS # | VP35, UniProt: Q6V1Q9 |
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| Catalog # | RPC23885 |
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| Order / More Info | Recombinant Zaire ebolavirus Polymerase cofactor VP35 (VP35) from BIOMATIK |
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| Product Specific References | n/a |
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